Water → HCID 18925367, compound

Participants

Reaction Steps

5-Acetyl-4-methyloxazole (5g) in dry diethylether (25ml) at -70° C. under a nitrogen atmosphere was treated dropwise with phenyllithium (1.8M solution in cyclohexane-diethylether, 27ml). After 45 minutes the mixture was allowed to warm to room temperature and water (10 ml) was added. The mixture was poured into saturated aqueous sodium chloride and extracted with dichloromethane. The product thus obtained was crystallised from diethylether to give 1-(4-methyl-5-oxazolyl)-1-phenylethanol, m.p. 102-104° C.

Provenance & Evidence