1-Bromo-2-methylpropane → HCID 54419340, compound

Participants

Reaction Conditions

Reaction Steps

A tetrahydrofuran solution of 2-methylpropylmagnesiumbromide prepared from 2.9 g of 2-methylpropylbromide, 0.47 g of magnesium and 20 ml of tetrahydrofuran was cooled to 10° C., a solution containing 1 g of 2-acetyl-3-t-butyloxycarbonylaminothiophene in 10 ml of tetrahydrofuran was dropwise added at 15° C. or less, and the mixture was stirred at room temperature for 2 hours. Thereafter a saturated aqueous ammonium chloride solution was dropwise added under cooling. The reaction mixture was extracted with ethyl acetate, washed with a saturated aqueous sodium chloride solution and dried over anhydrous sodium solfate. The solvent was distilled off under reduced pressure to obtain 1.2 g of the product. The yield was 98%.

Provenance & Evidence