HCID 18925401, compound → HCID 18925421, compound

HRID 1289085Notes

Reaction equation

HRID 1289085 reaction equation
[C:1]([C:4]1[S:5][CH:6]=[CH:7][C:8]=1[NH:9][C:10]([C:12]1[C:13]([C:18]([F:21])([F:20])[F:19])=[N:14][N:15]([CH3:17])[CH:16]=1)=[O:11])([CH3:3])=[CH2:2]>CO.[Pd]>[CH:1]([C:4]1[S:5][CH:6]=[CH:7][C:8]=1[NH:9][C:10]([C:12]1[C:13]([C:18]([F:19])([F:21])[F:20])=[N:14][N:15]([CH3:17])[CH:16]=1)=[O:11])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 18925401HCID 18925401, compound

Product 1

HCID 18925421HCID 18925421, compoundYield 79.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In 10 ml of methanol, 1 g of the compound prepared in Example 6 (Compound No. 1.71) was dissolved, 0.2 g of 5% Pd/C was added, and catalytic reduction was carried out at the room temperature for 8 hours under atmospheric pressure. After finishing the reaction, the catalyst was filtered and washed with methanol. The filtrate was concentrated under reduced pressure. The resulting oily material was sludged with hexane to obtain 0.8 g of the desired product as a crystal. The yield was 79%.

Workup

  1. customthe reaction
  2. filtrationthe catalyst was filtered
  3. washwashed with methanol
  4. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8c5c6db3f6484930ac08cd76de7b5217
Source dataset
uspto-grants-1998_05
Patent number
US05747518

Reaction notes

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