Sodium borohydride → HCID 18920436, compound

HRID 1289123Notes

Reaction equation

HRID 1289123 reaction equation
[OH:1][CH:2]([CH2:16][OH:17])[CH2:3][N:4]=[C:5]=[C:6]1[S:10][C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[CH:8][CH2:7]1.[BH4-].[Na+]>CO>[OH:1][CH:2]([CH2:16][OH:17])[CH2:3][NH:4][CH2:5][C:6]1[S:10][C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86750361HCID 86750361, compound

Product 1

HCID 18920436HCID 18920436, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(N-2,3-dihydroxypropyliminomethylidene)-2,2'-bithiophene was dissolved in 50 ml of methanol and stirred in ice bath. NaBH4 was added until bubbling stopped. After the methanol was removed under reduced pressure and the residue was extracted with dichloromethane. The extract was washed with saturated NaCl solution, dried over anhydrous magnesium sulfate and condensed under reduced pressure. The crude yellow glue-like product was thus obtained.

Workup

  1. customuntil bubbling
  2. customAfter the methanol was removed under reduced pressure
  3. extractionthe residue was extracted with dichloromethane
  4. washThe extract was washed with saturated NaCl solution
  5. dry with materialdried over anhydrous magnesium sulfate and condensed under reduced pressure
  6. customThe crude yellow glue-like product was thus obtained

Sources & evidence

ORD record
ord-39678622a48a40e9a0bba68377da911b
Source dataset
uspto-grants-1998_05
Patent number
US05747525

Reaction notes

Loading…