Water → (2,2':5',2''-Terthiophene)-5-carboxylic acid

HRID 1289130Notes

Reaction equation

HRID 1289130 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=[O:2].[OH2:18]>CC(C)=O>[C:1]([C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)([OH:18])=[O:2]

Participants

4

Reactant 2

HCID 962WaterHCID 454742(2,2':5',2''-Terthiophene)-5-carboxaldehyde

Product 1

HCID 159047(2,2':5',2''-Terthiophene)-5-carboxylic acidYield 51%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
15 °C

Procedure

0.27 g of 5-formyl-2,2':5',2"-terthiophene was dissolved in 50 ml of acetone and the temperature thereof was maintained at 15° C. CrO3 /H2O/H2SO4 solution (0.9 g/12 ml/0.2 ml) was dropped in slowly and stirred for 4 hours at 40° C. Then 50 ml of water was dropped in slowly, and the solution was filtered, washed with water, dried and a yellowish solid was thus obtained. After washed with chloroform, 150 mg of product was obtained and the melting point thereof was 239°-240° C. (yield: 51%).

Workup

  1. filtrationwas filtered
  2. washwashed with water
  3. customdried
  4. customa yellowish solid was thus obtained
  5. washAfter washed with chloroform

Sources & evidence

ORD record
ord-2969624fcd1942ed8cd43be65de4fc92
Source dataset
uspto-grants-1998_05
Patent number
US05747525

Reaction notes

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