HCID 18925567, compound → HCID 18925575, compound

Participants

Reaction Steps

4.41 g (8.8 mmol) of the benzyl ester obtained in step (a) in 70 ml of dioxane were hydrogenated in the presence of 132 mg of palladium (10%) on charcoal at 60° C. at a hydrogen pressure of 7 bars for 8 hours. After filtration of the reaction medium through Celite and evaporation, the residue was chromatographed on silica in the eluent CH2Cl2 /ethyl ether (95:5). After the product was converted into a paste in hexane, 2.63 g (73%) of the expected compound, melting at 187.5° C., were isolated.

Provenance & Evidence