Sodium Acetate → HCID 21191269, compound

HRID 1289156Notes

Reaction equation

HRID 1289156 reaction equation
[C:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=2)[CH:13]=O)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]2[CH:11]=[C:12](/[CH:13]=[C:30]3/[C:28](=[O:29])[NH:27][C:25](=[S:26])[S:24]/3)[CH:15]=[CH:16][CH:17]=2)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 21191249HCID 21191249, compound

Product 1

HCID 21191269HCID 21191269, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under a nitrogen atmosphere in a three-neck round bottom flask 3-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzaldehyde (0.73 g, 2.34 mmol), rhodanine (0.34 g, 2.55 mmol), sodium acetate (0.23 g, 2.80 mmol) and acetic acid (20 ml) were combined and then heated to reflux. The reaction mixture was allowed to reflux. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. temperatureheated to reflux
  2. temperatureto reflux

Sources & evidence

ORD record
ord-c7625b16b99640509b7f88ba54e09498
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Reaction notes

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