Sodium Acetate → HCID 86752509, compound

HRID 1289159Notes

Reaction equation

HRID 1289159 reaction equation
[C:1]([C:5]1[CH:20]=[CH:19][C:8]([CH2:9][O:10][C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[CH:14]=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[S:21]1[CH2:27][C:25](=[O:26])[NH:24][C:22]1=[S:23].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:5]1[CH:20]=[CH:19][C:8]([CH2:9][O:10][C:11]2[CH:12]=[C:13]([CH:14]=[C:27]3[S:21][C:22](=[S:23])[NH:24][C:25]3=[O:26])[CH:16]=[CH:17][CH:18]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 22566644HCID 22566644, compound

Product 1

HCID 86752509HCID 86752509, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The 3-[4-(t-butyl)benzyloxy]benzaldehyde (2 g, 7.5 mmol) was coupled to rhodanine (1.19 g, 9 mmol) by reacting the two in the presence of sodium acetate (2.42 g, 29 mmol) and acetic acid. The mixutre was heated to reflux and then refluxed overnight.

Workup

  1. temperatureThe mixutre was heated
  2. temperatureto reflux
  3. temperaturerefluxed overnight

Sources & evidence

ORD record
ord-4b9279c494fe44c69771d34399881b8d
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Reaction notes

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