反应详情

A suspension of 3.45 g (25.9 mmol) aluminum chloride in 15 ml methylene chloride was cooled under argon in an ice/salt bath and treated while stirring with a mixture of 4 g (21.2 mmol) 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro naphthalene (from Example 2) and 1.94 g (24.7 mmol) acetylchloride via a dropping funnel over a period of 0.5 hours. Then the cooling bath was removed, the mixture stirred for 2 hours at room temperature and the reaction quenched with ice. The organic layer was recovered and the aqueous layer extracted with 2×50 ml methylene chloride.

1. temperaturewas cooled under argon in an ice/salt bath
2. additiontreated
3. customThen the cooling bath was removed
4. customthe reaction quenched with ice
5. customThe organic layer was recovered
6. extractionthe aqueous layer extracted with 2×50 ml methylene chloride