Sodium Acetate → HCID 2854038, compound

HRID 1289161Notes

Reaction equation

HRID 1289161 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.C([O-])(=O)C.[Na+].[S:23]1[CH2:29][C:27](=[O:28])[NH:26][C:24]1=[S:25]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH:14]=[C:29]3[S:23][C:24](=[S:25])[NH:26][C:27]3=[O:28])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 5806474-[(4-Chlorobenzyl)oxy]benzaldehydeHCID 1201546Rhodanine

Product 1

HCID 2854038HCID 2854038, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under a nitrogen atmosphere in a round bottom flask 4-[(4-chlorophenyl)methoxy]benzaldehyde (0.40 g, 1.62 mmol) was dissolved in acetic acid (8.1 ml) while stirring. To this solution was added sodium acetate (0.47 g, 5.7 mmol) followed by the addition of rhodanine (0.22 g, 1.65 mmol). The reaction mixture was heated to the reflux temperature and maintained at this temperature. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. temperatureThe reaction mixture was heated to the reflux temperature
  2. temperaturemaintained at this temperature

Sources & evidence

ORD record
ord-bc836c04fba245719305a8524fa18d95
Source dataset
uspto-grants-1998_05
Patent number
US05747517

Reaction notes

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