2-Bromophenol → 1-Bromo-2-(methoxymethoxy)benzene

Participants

Reaction Steps

To a solution of 2-bromophenol (0.67 ml, 5.8 mmol) and diisopropylethylamine (1.1 ml, 6.4 mmol) was added chloromethyl methyl ether (0.49 ml, 6.4 mmol). The reaction mixture was stirred at ambient temperature for 2 h, quenched with sat'd NaHCO3 and diluted with CH2Cl2. The organic phase was washed with water and dried over Na2SO4 to afford 700 mg (58%) of the title compound.

Provenance & Evidence