HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine → HCID 9906200, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine | HCID 3520 | — |
| Reactant | HCID 10708002 | HCID 10708002 | — |
| Reactant | methyl 3-methylsulfonyl-4-bromobenzoate | HCID 11109119 | — |
| Reactant | Potassium trifluoroacetate | HCID 23662811 | — |
| Catalyst | Tetramethylammonium iodide | HCID 6381 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 9906200 | HCID 9906200 | — |
Reaction Steps
1.1 g of methyl 3-methylsulfonyl-4-trifluoromethylbenzoate [m.p. 146°-147°; obtainable by reaction of methyl 3-methylsulfonyl-4-bromobenzoate with potassium trifluoroacetate in the presence of CuI and tetramethylammonium iodide in toluene] are added to a solution of 928 mg of guanidine in 15 ml of methanol. The mixture is stirred for 45 minutes at 50° and, after removal of the solvent and customary working up, N-diaminomethylene3-methylsulfonyl-4-trifluoromethylbenzamide, m.p. 233°-234°, is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05747539 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-1e03e6046513426fbf3827f81c803807 |
| Source note | uspto-grants-1998_05 |