Pentafluorophenyl Trifluoroacetate → HCID 136351292, compound

HRID 1289238Notes

Reaction equation

[CH3:1][N:2]([C:18]1[CH:19]=[CH:20][C:21]([C:24]([O:26][C:27]2[C:32]([F:33])=[C:31]([F:34])[C:30]([F:35])=[C:29]([F:36])[C:28]=2[F:37])=[O:25])=[N:22][CH:23]=1)[CH:3]1[C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][C:6]=2[CH2:5][CH2:4]1)[N:13]=[C:12]([CH3:16])[NH:11][C:10]3=[O:17].F[C:39](F)(F)[C:40](OC1C(F)=C(F)C(F)=C(F)C=1F)=O>>[CH3:16][C:12]1[NH:11][C:10](=[O:17])[C:9]2[C:14](=[CH:15][C:6]3[CH2:5][CH2:4][CH:3]([N:2]([C:18]4[CH:19]=[CH:20][C:21]([C:24]([O:26][C:27]5[C:32]([F:33])=[C:31]([F:34])[C:30]([F:35])=[C:29]([F:36])[C:28]=5[F:37])=[O:25])=[N:22][CH:23]=4)[CH2:1][C:39]#[CH:40])[C:7]=3[CH:8]=2)[N:13]=1

Participants

Reactant 2

HCID 4327891Pentafluorophenyl Trifluoroacetate

HCID 135848306HCID 135848306, compound

Product 1

HCID 136351292HCID 136351292, compound

Procedure

Using an analogous procedure to that described in section (5) of Example 6, 5-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)]pyridine-2-carboxylic acid was reacted with pentafluorophenyl trifluoroacetate to give pentafluorophenyl 5-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]-pyridine-2-carboxylate as a foam.

Sources & evidence

ORD record: ord-98b82ff536d14eb7a6a1b3702cc76ead
Source dataset: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05747499

Reaction notes

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