HCID 86752524, compound → HCID 57056592, compound

Participants

Reaction Steps

To a solution of methyl (2S)-2-(benzyloxycarbonylamino)-4-(2-methoxy-carbonylmethyltetrazol-5-yl)butyrate (0.820 g, 2.10 mmol) in ethyl acetate (100 ml) was added 10% Pd/C (0.220 g). The black reaction mixture was stirred at room temperature for 15 hours under a hydrogen atmosphere. The catalyst was removed by filtration and the filtrate was concentrated to give methyl (2S)-2-amino-4-(2-methoxycarbonylmethyl-tetrazol-5-yl)butyrate (0.410 g, 76%) as a colourless oil. This was immediately used in section (5) below without further purification.

Provenance & Evidence