Ethyl Acetate → HCID 86752529, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl (2S)-2-(benzyloxycarbonylamino)-4-[1-(2-methoxy-carbonylethyl) tetrazol-5-yl]butyrate (0.233 g, 0.575 mmol) in ethyl acetate (25 ml) was added 10% Pd/C. (0.045 g). The resulting black mixture was degassed and then stirred at 24° C. for 4 hours under hydrogen. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to a colourless viscous oil that dried in vacuo over phosphorous pentoxide. There was thus obtained methyl (2S)-2-amino-4-[1-(2-methoxycarbonylethyl)tetrazol-5-yl]butyrate (0.146 g, 94%) as a colourless viscous oil. This was used in the next step without any further purification.

Provenance & Evidence