m-Chloroperbenzoic acid → HCID 178448801, compound

Participants

Reaction Steps

34.70 g of 2-amino-4-isobutylamino-6-chloropyrimidine are dissolved in 250 ml of ethanol. 81.50 g of metachloroperbenzoic acid, in solution in 350 ml of ethanol, are added dropwise and while keeping the temperature of the reaction mixture at 20° C. After stirring for 2 h 30 min, the precipitate formed is filtered on sintered glass, washed with 100 ml of ethyl ether and then taken up in 100 ml of water. The pH is adjusted to 8 by addition of concentrated sodium hydroxide solution. After stirring for 1 hour, the precipitate is filtered on sintered glass, washed with 3×50 ml of water and dried under vacuum over phosphorus pentoxide at 50° C. 11.30 g of 2-amino-4-isobutylamino-6-chloropyrimidine 3-oxide are obtained.

Provenance & Evidence