Chlorosuccinimide → HCID 178448814, compound

Participants

Reaction Steps

6.30 g of 2-amino-4-isobutylamino-6-chloropyrimidine 3-oxide are suspended in 110 ml of ethanol. 4.85 g of N-chlorosuccinimide are added. The reaction mixture is heated under reflux for 2 hours and then evaporated to dryness. The residue is taken up in 50 ml of water. The pH is adjusted to 8 by addition of concentrated sodium hydroxide solution. The precipitate formed is filtered on sintered glass, washed with water until neutral and dried under vacuum over phosphorus pentoxide. It is recrystallized from 150 ml of ethanol. 4.30 g of 2-amino-4-isobutylamino-5,6-dichloropyrimidine 3-oxide are obtained.

Provenance & Evidence