Water → HCID 19372928, compound

Participants

Reaction Steps

A mixture of 2-acetylaminomethyl-5-(4-chlorobutyryl)thiophene (15 g) in triethylsilane (21.6 ml) and trifluoroacetic acid (70 ml) was stirred at room temperature for 10 hours. The reaction mixture was poured into water, extracted with ethyl acetate, and dried over magnesium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give 10 g of 2-acetylaminomethyl-5-(4-chlorobutyl)thiophene.

Provenance & Evidence