Potassium Iodide → HCID 19372889, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-acetylaminomethyl-5-(4-chlorobutyryl)thiophene (2.6 g), 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (2.7 g), potassium carbonate (3.0 g), potassium iodide (1.6 g), dimethylformamide (20 ml), and toluene (20 ml) was stirred at 60° C. for 6 hours. The reaction mixture was poured into water, and the precipitated crystals were filtered off, followed by recrystallization from ethanol to give 0.9 g of 3-(1-(4-(5-acetylaminomethyl -2-thienyl)-4-oxobutyl)piperidin-4-yl)-6-fluoro-1,2-benzisoxazole as white crystals, m.p. 140-142° C.

Provenance & Evidence