Bromine → HCID 18920740, compound

HRID 1289345Notes

Reaction equation

HRID 1289345 reaction equation
[Br:1]Br.[CH2:3]([O:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH2:21][CH3:22])[CH:15]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]>C(Cl)(Cl)Cl>[Br:1][C:17]1[C:18]([CH3:20])=[CH:19][C:14]([O:13][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[CH:15][C:16]=1[CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 24408BromineHCID 18920737HCID 18920737, compound

Product 1

HCID 18920740HCID 18920740, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of bromine (5.44 g, 0.034 mol) in chloroform (50 ml) was added dropwise to a stirred, refluxing solution of 1-decyloxy-3-ethyl-5-methylbenzene (9.4 g, 0.034 mol) in chloroform (200 ml). The reaction mixture was then allowed to cool, washed with water and dried (MgSO4). The solvent was removed and the residue purified by gravity column chromatography (silica gel/dichloromethane) to yield a pale orange oil.

Workup

  1. temperatureto cool
  2. washwashed with water
  3. dry with materialdried (MgSO4)
  4. customThe solvent was removed
  5. customthe residue purified by gravity column chromatography (silica gel/dichloromethane)
  6. customto yield a pale orange oil

Sources & evidence

ORD record
ord-c72932426d774027931f009155ddd2e7
Source dataset
uspto-grants-1998_05
Patent number
US05750050

Reaction notes

Loading…