Acrylic Acid → HCID 18920854, compound

Participants

Reaction Steps

First, 2.3 g of 2,3-difluoro-4'-[8,8-bis(6-hydroxyhexyl)octyl]oxybiphenyl, 0.8 g of acrylic acid, 2.9 g of triphenylphosphine, and 50 ml of tetrahydrofuran were placed in a 100 ml flask. Then, 1.93 g of ethyl azodicarboxylate was added dropwise to the reaction mixture under ice water cooling. Thereafter, the reaction mixture was allowed to warm to room temperature and stirred for 2 hours. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (eluent: benzene) to obtain 1.31 g of 2,3-difluoro-4'-[8,8-bis(6-acryloyloxyhexyl)octyl]oxybiphenyl (Y: 47.1%). The compound thus obtained was liquid at room temperature. The compound had a purity of 99.5% by HPLC and 1 spot by TLC.

Provenance & Evidence