化工社化工社 化学情報印刷レポート · 研究参考用
Veratrylamine → 4-bromo-6-[3-(4-chlorophenyl)-3-hydroxypropyloxy]-5-(3,4-dimethoxybenzylamino)-3(2H)pyridazinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Veratrylamine | HCID 79832 | — |
| 反応物 | 4,5-dibromo-6-[3-(4-chlorophenyl)-3-hydroxypropyloxy]-3(2H)pyridazinone | HCID 54023701 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 4-bromo-6-[3-(4-chlorophenyl)-3-hydroxypropyloxy]-5-(3,4-dimethoxybenzylamino)-3(2H)pyridazinone | HCID 15390859 | 68.5% |
反応手順
From 300 mg of 4,5-dibromo-6-[3-(4-chlorophenyl)-3- hydroxypropyloxy]-3(2H)pyridazinone, 228 mg of 3,4-dimethoxybenzylamine and 69 mg of triethylamine, 246 mg of the title compound was prepared in the same manner as in Example 1, as white crystals having a melting point of 190°-196° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05750523 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-e9a8ce52d8c641d4981556457c6d7030 |
| 出典メモ | uspto-grants-1998_05 |