HCID 23206558, compound → HCID 23206535, compound

Participants

Reaction Conditions

Reaction Steps

15.4 g of 1-(2,2,2-trichloroethoxycarbonyl)-6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-2-phosphonic acid diethyl ester is dissolved in 400 ml of methanol, mixed with 7.2 g of zinc powder and stirred under nitrogen for 1.5 hours at 90° C. It is filtered on diatomaceous earth and the filtrate is concentrated by evaporation. The crude product is purified by column chromatography and recrystallized from isopropyl ether.

Provenance & Evidence