HCID 18921478, compound → HCID 18921482, compound

Participants

Reaction Steps

Dissolved in 100 ml of methanol were 3.53 g (10.0 mmol) of 5-benzyloxy-2-(t-butoxycarbonylaminomethyl)indane. After 0.3 g of 10% palladium-carbon was added to the solution, the mixture was stirred for 4 hours under a hydrogen atmosphere. The catalyst was separated by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2) to obtain 2.79 g of a colorless oily substance. Yield: 94%.

Provenance & Evidence