Ethyl bromoacetate → HCID 20077201, compound

Participants

Reaction Steps

Dissolved in 20 ml of acetone were 1.85 g (6.20 mmol) of 2-(t-butoxycarbonylaminomethyl)-5-hydroxyindane, and 1.52 g (11.0 mmol) of potassium carbonate and 1.10 g (6.60 mmol) of ethyl bromoacetate were added to the solution. The mixture was refluxed for 3.5 hours. After cooling, solids were separated by filtration, and the filtrate was concentrated. The resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2) to obtain 1.90 g of a colorless crystal. Yield; 80%.

Provenance & Evidence