Imidazole → HCID 54462525, compound

HRID 1289461Notes

Reaction equation

HRID 1289461 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14]Cl)[C:8](=[O:16])[C:7](=[O:17])[NH:6]2.[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>>[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][C:21]1[NH:20][CH:24]=[CH:23][N:22]=1)[C:8](=[O:16])[C:7](=[O:17])[NH:6]2

Participants

3

Reactant 2

HCID 795ImidazoleHCID 54154081HCID 54154081, compound

Product 1

HCID 54462525HCID 54462525, compound

Procedure

392 mg (1 mmol) of 2-[(6 trifluoromethylquinoxaline-2,3-dion-1-yl)ethyl chloride is heated with 150 mg (2.2 mmol) of imidazole for 3 hours to 150° C. bath temperature. The organic phase is concentrated by evaporation with dispersion in 10 ml of ethyl acetate and 10 ml of water, and the residue is chromatographed on silica gel with methanol:butanol:water:ammonia=75:25:17:3 as eluant. 54 mg (17% of theory) of 2-((6 trifluoromethylquinoxaline-2,3-dion-1-yl)ethylimidazole of melting point>250° C. is obtained.

Workup

  1. concentrationThe organic phase is concentrated by evaporation with dispersion in 10 ml of ethyl acetate
  2. custom10 ml of water, and the residue is chromatographed on silica gel with methanol

Sources & evidence

ORD record
ord-7b3f04c6e9044fdc9dd25f0634b2ff91
Source dataset
uspto-grants-1998_05
Patent number
US05750525

Reaction notes

Loading…