Nitric Acid → HCID 17800776, compound

HRID 1289462Notes

Reaction equation

HRID 1289462 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][CH2:14][O:15][CH3:16])[C:8](=[O:17])[C:7](=[O:18])[NH:6]2.[N+:21]([O-])([OH:23])=[O:22]>S(=O)(=O)(O)O>[F:20][C:2]([F:1])([F:19])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[N+:21]([O-:23])=[O:22])[N:9]([CH2:13][CH2:14][O:15][CH3:16])[C:8](=[O:17])[C:7](=[O:18])[NH:6]2

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 4589432HCID 4589432, compound

Product 1

HCID 17800776HCID 17800776, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

100 mg of 6-trifluoromethyl-1-(1-methoxyeth-2-yl)-1,2,3,4-tetrahydro-2,3-dioxoquinoxaline is suspended in 1 ml of concentrated sulfuric acid, mixed at 4° C. with 0.1 ml of a mixture of concentrated sulfuric acid:concentrated nitric acid 1:1 and stirred for 1 hour at 4° C. Then, everything is dissolved. Then, it is poured on ice and the settled precipitate is suctioned off. 59 mg (50% of theory) of 6-trifluoromethyl-7-nitro-1-(1-methoxyeth-2-yl)-1,2,3,4-tetrahydro-2,3-dioxoquinoxaline is obtained.

Workup

  1. dissolutionThen, everything is dissolved
  2. additionThen, it is poured on ice

Sources & evidence

ORD record
ord-52c7026f3d034abba7860b6eb4022df1
Source dataset
uspto-grants-1998_05
Patent number
US05750525

Reaction notes

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