4-Fluoroaniline → 6-Methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-(4-fluorophenylamino)pyrimidine hydrochloride

Participants

Reaction Steps

After 4-fluoroaniline(0.8 ml, 8.4 mmol) was added to a mixture solution of 6-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloropyrimidine(1.5 g, 5.5 mmol) and dimethylformamide (10 ml), 1.5 g of the title compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Provenance & Evidence