N,N-Dimethylaniline → HCID 178478351, compound

Participants

Reaction Steps

A mixture solution of phosphorous oxychloride(49 ml), N,N-dimethylaniline(8.0 ml) and 2,4-dihydroxycyclopenta[d]pyrimidine(15.4 g, 0.1 mol) prepared in the above Step 2 was heated to reflux for 3 hours and cooled to a room temperature. After the reaction mixture was diluted with dichloromethane, the diluted solution was added to ice water, while maintaining the temperature of the reaction system below 10° C. The reaction mixture was extracted with dichloromethane, dried over anhydrous sodium sulfate and concentrated in vacuo to give 2.8 g of titled compound as an oily form. (Yield: 15%)

Provenance & Evidence