1-Methyl-1,2,3,4-tetrahydroisoquinoline → HCID 18921721, compound

HRID 1289529Notes

Reaction equation

HRID 1289529 reaction equation
[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][NH:3]1.[Cl:12][C:13]1[NH:18][C:17]2=[CH:19][CH:20]=[CH:21][C:16]2=[C:15](Cl)[N:14]=1>>[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]1[C:15]1[N:14]=[C:13]([Cl:12])[NH:18][C:17]2=[CH:19][CH:20]=[CH:21][C:16]=12

Participants

3

Reactant 2

HCID 922141-Methyl-1,2,3,4-tetrahydroisoquinolineHCID 178478351HCID 178478351, compound

Product 1

HCID 18921721HCID 18921721, compoundYield 62.4%

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that 1-methyl-1,2,3,4-tetrahydroisoquinoline(1.7 g, 11.55 mmol) and 2,4-dichlorocyclopenta[d]pyrimidine(2.0 g, 10.5 mmol) prepared in the above Step 3 were used as starting materials, 1.95 g of the title compound was prepared. (Yield: 62%)

Sources & evidence

ORD record
ord-9c19b97dd9444b8599f687c5e7aa03a6
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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