Dimethylformamide → HCID 18921711, compound

Participants

Reaction Conditions

Reaction Steps

A mixture solution of 1-methyl-1,2,3,4-tetrahydroisoquinoline(2.6 g, 17.4 mmol), triethylamine(2.8 mL), N,N-dimethylformamide (20 ml) and 2,4-dichloro-5,6,7,8-tetrahydroquinazoline(3.2 g, 15.8 mmol) prepared in the above Step 2 were stirred at 80° C. for 3 hours and cooled. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated. The residue was purified with silica gel column chromatography to give 3.1 g of the titled compound. (Yield: 62.5%)

Provenance & Evidence