1,2,3,4-Tetrahydroisoquinoline → 6-Ethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloropyrimidine

Participants

Reaction Steps

In accordance with the same procedure as in Step 1 of Example 1, except that 1,2,3,4-tetrahydroisoquinoline(3.5 ml, 28 mmol), triethylamine(3.9 ml, 28 mmol),N,N-dimethylformamide (20 ml) and 6-ethyl-2,4-dichloropyrimidine(4.9 g, 27.7 mmol) prepared in Preparation 2 were used as starting materials, 5.0 g of the titled compound was prepared. (Yield: 66%)

Provenance & Evidence