4-Fluoro-2-methylaniline → 6-Ethyl-2-(2-methyl-4-fluorophenylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride

Participants

Reaction Steps

After 2-methyl-4-fluoroaniline(0.57 ml, 5.13 mmol) was added to a mixture solution of 6-ethyl-4-(1,2,3,4-tetrahydroisoquinoline-2-yl)-2-chloropyrimidine(0.7 g, 2.56 mmol) and dimethylformamide(5 ml), 0.55 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Provenance & Evidence