1,2,3,4-Tetrahydroisoquinoline → 2-Chloro-5,6-dimethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

Participants

Reaction Steps

In accordance with the same procedure as in Step 1 of Example 1, except that 1,2,3,4-tetrahydroisoquinoline(2.9 g, 23 mmol) and 5,6-dimethyl-2,4-dichloropyrimidine(3.8 g, 21 mmol) and 1,2,3,4-tetrahydroisoquinoline(2.9 g, 23 mmol) prepared in Step 1 of Example 12 were used as starting materials, 3.95 g of the titled compound was prepared.

Provenance & Evidence