1,2,3,4-Tetrahydroisoquinoline → HCID 18921790, compound

HRID 1289550Notes

Reaction equation

HRID 1289550 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[Cl:11][C:12]1[N:17]=[C:16](Cl)[C:15]([CH3:19])=[C:14]([CH2:20][CH3:21])[N:13]=1>>[CH3:19][C:15]1[C:16]([N:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:1]2)=[N:17][C:12]([Cl:11])=[N:13][C:14]=1[CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 18921712HCID 18921712, compound

Product 1

HCID 18921790HCID 18921790, compoundYield 66%

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that 1,2,3,4-tetrahydroisoquinoline(3.5 ml, 28 mmol) and 2,4-dichloro-5-methyl-6-ethylpyrimidine(4.9 g, 27.7 mmol) prepared in Preparation 4 were used as starting materials, 5.0 g of the titled compound was prepared.

Sources & evidence

ORD record
ord-c37d73f604674a78973e40b14ec8b66c
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

Loading…