1,2,3,4-Tetrahydroisoquinoline → HCID 18921760, compound

Participants

Reaction Steps

In accordance with the same procedure as in Step 1 of Example 1, except that a mixture solution of 1,2,3,4-tetrahydroisoquinoline(2.8 ml, 22 mmol), triethylamine(3.4 ml, 24 mmol), N,N-dimethylformamide(10 ml) and 2,4-dichloro-5,6,7,8-tetrahydroquinazoline(4.0 g, 20 mmol) prepared in Step 2 of Example 32 were used as starting materials, 4.7 g of the titled compound was prepared. (Yield: 78.4%)

Provenance & Evidence