7-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine → HCID 178429392, compound

HRID 1289573Notes

Reaction equation

HRID 1289573 reaction equation
[CH3:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([OH:9])[CH:3]=1.[CH3:10][CH:11]1[C:16]2[S:17][CH:18]=[CH:19][C:15]=2[CH2:14][CH2:13][NH:12]1>>[CH3:1][C:2]1[N:7]=[C:6]([N:12]2[CH2:13][CH2:14][C:15]3[CH:19]=[CH:18][S:17][C:16]=3[CH:11]2[CH3:10])[N:5]=[C:4]([OH:9])[CH:3]=1

Participants

3

Reactant 2

HCID 145481697-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridineHCID 178429342HCID 178429342, compound

Product 1

HCID 178429392HCID 178429392, compoundYield 70.4%

Procedure

In accordance with the same procedure as in Step 2 of Example 57, except that 6-methyl-2-chloro-4-hydroxypyrimidine(6 g, 37.5 mmol) prepared in Step 1 of Example 57, and 7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (12.07 g, 78.75 mmol) prepared in preparation 1 were used as starting materials, 6.9 g of the titled compound was prepared.

Sources & evidence

ORD record
ord-7d452aa105124a3588edb72555fe0ef8
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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