4-Fluoro-2-methylaniline → HCID 67627995, compound

Participants

Reaction Steps

After 2-methyl-4-fluoroaniline(0.82 ml, 7.35 mmol) was added to a mixture solution of (R)-5,6-dimethyl-2-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chloropyrimidine(1.0 g, 3.5 mmol) prepared in the above Step 2 and dimethylformamide (10 ml), 1.2 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Provenance & Evidence