1,2,3,4-Tetrahydroisoquinoline → HCID 178433063, compound

HRID 1289589Notes

Reaction equation

HRID 1289589 reaction equation
[CH3:1][C:2]1[C:3]([OH:10])=[N:4][C:5](Cl)=[N:6][C:7]=1[CH3:8].[CH2:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][NH:12]1>>[CH3:1][C:2]1[C:3]([OH:10])=[N:4][C:5]([N:12]2[CH2:13][CH2:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11]2)=[N:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 178432892HCID 178432892, compound

Product 1

HCID 178433063HCID 178433063, compoundYield 81%

Procedure

In accordance with the same procedure as in Step 2 of Example 57, except that 5,6-dimethyl-2-chloro-4-hydroxypyrimidine (6.0 g, 37.8 mmol) prepared in the Step 2 of Example 65 and 1,2,3,4-tetrahydroisoquinoline(10 ml, 79.9 mmol) were used as starting materials, 7.8 g of the titled compound was prepared. (Yield: 81%)

Sources & evidence

ORD record
ord-b7141dffee0a48b092094153b3473e4b
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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