1-Methyl-1,2,3,4-tetrahydroisoquinoline → HCID 178421595, compound

HRID 1289598Notes

Reaction equation

HRID 1289598 reaction equation
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1.[CH3:13][CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH2:16][NH:15]1>>[CH3:13][CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH2:16][N:15]1[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 922141-Methyl-1,2,3,4-tetrahydroisoquinolineHCID 178517812HCID 178517812, compound

Product 1

HCID 178421595HCID 178421595, compoundYield 34.5%

Procedure

In accordance with the same procedure as in Step 2 of Example 57, except that 2-chloro-4-hydroxy-5,6,7,8-tetrahydroquinazoline (2.0 g, 10.8 mmol) prepared in the above Step 1 and 1-methyl-1,2,3,4-tetrahydroisoquinoline(3.3 g, 22.4 mmol) were used as starting materials, 1.1 g of the titled compound was prepared. (Yield: 34.5%)

Sources & evidence

ORD record
ord-594ec20bf9f743909597397537848229
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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