Lawesson's reagent → HCID 54540440, compound

HRID 1289620Notes

Reaction equation

HRID 1289620 reaction equation
[C:1]([C:5]1[C:10]2[O:11][CH2:12][C:13]([CH3:15])([CH3:14])[C:9]=2[CH:8]=[C:7]([C:16]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:32])=CC=1>C1(C)C=CC=CC=1>[C:1]([C:5]1[C:10]2[O:11][CH2:12][C:13]([CH3:15])([CH3:14])[C:9]=2[CH:8]=[C:7]([C:16]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[S:32])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 9796297HCID 9796297, compound

Product 1

HCID 54540440HCID 54540440, compoundYield 159.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-tert-Butyl-2,3-dihydro-3,3-dimethyl-5-(2-furoyl)benzo[b]furan (600 mg, 2 mmol) and Lawesson's reagent (404 mg, 1 mmol) in dry toluene (10 mL) is refluxed in an argon atmosphere. The mixture is cooled and the toluene evaporated. The resulting solid was purified by flash chromatography on silica gel to give 502 mg (80%) of the title compound as a yellowish crystals.

Workup

  1. temperatureThe mixture is cooled
  2. customthe toluene evaporated
  3. customThe resulting solid was purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-016e87b262954ff5b1ee86de50d3b847
Source dataset
uspto-grants-1998_05
Patent number
US05750543

Reaction notes

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