HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 4-Propyl-5-methyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 2-Phenylmethyl-4-propyl-5-methyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide | HCID 18922254 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Propyl-5-methyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide | HCID 18922253 | 81.4% |
Reaction Steps
A mixture of 2-phenylmethyl-5-methyl-4-propyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide (4.15 g), 10% Pd/C (2.0 g), and ammonium formate (8.0 g) and methanol was stirred overnight at room temperature. The solvent was removed and the crude product was purified by flash chromatography to afford 2.3 g (80.9%) of 5-methyl-4-propyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide (Formula IV: R1 =propyl; R2 =H; R3 =CH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750546 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-1d7a46a692044ae4ad8ce756a5095a2a |
| Source note | uspto-grants-1998_05 |