反应详情

A solution of (N-carbobenzyloxyaminosulfonyl)-2-(3-methylbutyl)sarcosine methyl ester (20.6 g, 53.17 mmol) in 200 ml of methanol under nitrogen was cooled to 0° C. and 1.5 g of 10% Pd/C was added. The mixture was placed on a Parr Apparatus at 50 psi and hydrogenated for 3.5 hours. The catalyst was removed on a pad of CELITE® and the filtrate was concentrated in vacuo to afford 13.24 g (98.6%) of N-(aminosulfonyl)-2-(3-methylbutyl)sarcosine methyl ester (Formula V: R=CH3 ; R1 =(CH2)2CH(CH3)2 ; R2 =H; R3 =CH3) as an oil.

1. customThe catalyst was removed on a pad of CELITE®
2. concentrationthe filtrate was concentrated in vacuo