Methyl iodide → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 1289664Notes

Reaction equation

HRID 1289664 reaction equation
[CH3:1][I:2].[CH:3]1([CH2:6][O:7][C:8]2[C:12]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[N:11][S:10][N:9]=2)[CH2:5][CH2:4]1>CC(C)=O>[I-:2].[CH:3]1([CH2:6][O:7][C:8]2[C:12]([C:13]3[CH:14]=[N+:15]([CH3:1])[CH:16]=[CH:17][CH:18]=3)=[N:11][S:10][N:9]=2)[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190752393-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190754673-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.25 ml, 4 mmol) and 3-(3-cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine (400 mg, 1.7 mmol) in acetone (5 ml) was stirred at room temperature for 36 h. The title compound precipitated from the solution and was collected by filtration to yield 0.41 g (65%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.41 g (65%)

Sources & evidence

ORD record
ord-3bf20743c21c4b9ab8e42b9d01a60034
Source dataset
uspto-grants-1998_05
Patent number
US05750541

Reaction notes

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