HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Pyridin-3-yl-1,2,5-oxadiazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | alpha-Oximino-3-pyridylacetamidoxime | HCID 136341185 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Pyridin-3-yl-1,2,5-oxadiazol-3-amine | HCID 1415523 | — |
Reaction Steps
Crude alpha-oximino-3-pyridylacetamidoxime (5 g) and phosphorus pentachloride (5 g) was refluxed in dry ether (250 ml) for 6 h. Water and potassium carbonate to alkaline pH was added and the phases separated. The aqueous phase was extracted with ether and the combined ether phases dried. Evaporation of the ether phases gave the title compound in 850 mg yield; M+ : 162.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750541 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-259f079a0281488293f31132569fc423 |
| Source note | uspto-grants-1998_05 |