Tetrahydrofuran → HCID 18922202, compound

Participants

Reaction Steps

The synthesis was carried out according to the method of Example 18-(1). 4-Chlorosalicylic acid (8.5 g), : 60% oil sodium hydride (4.5 g), n-propyl iodide (50 g), tetrahydrofuran (30 ml) and dimethylformamide (25 ml) were used as reagents. The mixture was reacted for 1 hour at 90° C. After the reaction, the mixture was chromatographed on silica gel (hexane-ethyl acetate) to give 7.63 g of a colorless transparent liquid (yield 63%).

Provenance & Evidence