Hydrochloric Acid → HCID 18922221, compound

Participants

Reaction Steps

The synthesis method of Example 7-(3) was applied. The compound (3.39 g) obtained in (4) above, a 1N aqueous sodium hydroxide solution (26 ml), methyl isothiocyanate (1.9 g) and tetrahydrofuran (30 ml) were used as reagents. The mixture was stirred at room temperature for 5 hours and neutralized with 3N hydrochloric acid. The resulting powder was collected by filtration and subjected to silica gel column chromatography (chloroform-methanol) and recrystallization from chloroform-methanol to give 917 mg of white crystals (yield 20%).

Provenance & Evidence