Water → 1--Naphthoic acid 2-amidinohydrazide

HRID 1289766Notes

Reaction equation

HRID 1289766 reaction equation
[C:1]1([C:11]([NH:13][NH2:14])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(O)(O)(=O)=O.C[NH:21][C:22](=[NH:24])S.[OH-].[Na+].O>CO>[C:22]([NH:14][NH:13][C:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:12])(=[NH:21])[NH2:24]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 726891-NaphthohydrazideHCID 178485225HCID 178485225, compound

Product 1

HCID 1785131641--Naphthoic acid 2-amidinohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The synthesis method of Example 1-(1) was applied. The compound (18.3 g) obtained in (2) above, methylisothiourea sulfate (81.6 g), sodium hydroxide (11.7 g), water (90 ml) and methanol (180 ml) were used as reagents and the mixture was reacted at 60° C. for 48 hours to give 39.7 g of a yellow solid. A portion (21.2 g) from the obtained solid was used in the next reaction.

Workup

  1. customthe mixture was reacted at 60° C. for 48 hours

Sources & evidence

ORD record
ord-dce170320df34363819f8a332f5e014f
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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