HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Amino-3-(4-chloro-1-naphthyl)-1-[methylamino(thiocarbonyl)]-1H-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Amino-5-(4-chloro-1-naphthyl)-1H-1,2,4-triazol | HCID 10752854 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-Amino-3-(4-chloro-1-naphthyl)-1-[methylamino(thiocarbonyl)]-1H-1,2,4-triazole | HCID 10591607 | 5% |
Reaction Steps
The synthesis method of Example 7-(3) was applied. The compound (2.19 g) obtained in (4) above, a 1N sodium hydroxide solution (10.0 ml), methyl isothiocyanate (1.38 g) and tetrahydrofuran (10 ml) were used as reagents. After the reaction, silica gel column chromatography (chloroform) and recrystallization from chloroform gave 135 mg of white crystals (yield 5% from methyl 4-chloro-1-naphthoate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750545 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-2974aa6beeca4219865fcf73d63b5b3e |
| Source note | uspto-grants-1998_05 |