Acetic Anhydride → HCID 18922226, compound

HRID 1289776Notes

Reaction equation

HRID 1289776 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([NH2:7])[N:4]([C:8]([NH:10][CH3:11])=[S:9])[N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[C:12]([NH:1][C:2]1[N:6]=[C:5]([NH2:7])[N:4]([C:8]([NH:10][CH3:11])=[S:9])[N:3]=1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 10725863HCID 10725863, compound

Product 1

HCID 18922226HCID 18922226, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To the compound (3.00 g) obtained in Example 31 and pyridine (25 ml) was gradually added dropwise acetic anhydride (2.1 ml) under ice-cooling. The mixture was stirred at 0° C.-room temperature for 66 hours and the resulting crystals were collected by filtration. The crystals were washed with hexane-ethyl acetate and dried to give 2.98 g of white powdery crystals (yield 80%).

Workup

  1. temperaturecooling
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were washed with hexane-ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-4362d6ef743841ef9950f9d4e6c0ab48
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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